Absolute Configuration of Alkaloids from Uncaria longiflora through Experimental and Computational Approaches

Fatimah Salim; Yusri Mohd Yunus; El Hassane Anouar; Khalijah Awang; Moses Langat; Geoffrey A. Cordell; Rohaya Ahmad

doi:10.1021/acs.jnatprod.8b00380

Absolute Configuration of Alkaloids from Uncaria longiflora through Experimental and Computational Approaches

Fatimah Salim
, Yusri Mohd Yunus
, El Hassane Anouar
, Khalijah Awang
, Moses Langat
, Geoffrey A. Cordell
, Rohaya Ahmad

Chemistry

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

The structure elucidation of three new alkaloids named isoformosaninol (1), formosaninol (2), and longiflorine (3), isolated from the leaves of Uncaria longiflora var. pteropoda (Miq.) Ridsdale, along with their biosynthetic pathways are discussed. Their absolute structures were determined through a combination of physical data interpretation and quantum chemical calculations using the time-dependent density functional theory (TDDFT) method.

Original language	English
Pages (from-to)	2933-2940
Number of pages	8
Journal	Journal of Natural Products
Volume	82
Issue number	11
DOIs	https://doi.org/10.1021/acs.jnatprod.8b00380
State	Published - 22 Nov 2019

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10.1021/acs.jnatprod.8b00380

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abstract = "The structure elucidation of three new alkaloids named isoformosaninol (1), formosaninol (2), and longiflorine (3), isolated from the leaves of Uncaria longiflora var. pteropoda (Miq.) Ridsdale, along with their biosynthetic pathways are discussed. Their absolute structures were determined through a combination of physical data interpretation and quantum chemical calculations using the time-dependent density functional theory (TDDFT) method.",

author = "Fatimah Salim and Yunus, \{Yusri Mohd\} and Anouar, \{El Hassane\} and Khalijah Awang and Moses Langat and Cordell, \{Geoffrey A.\} and Rohaya Ahmad",

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year = "2019",

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AU - Salim, Fatimah

AU - Yunus, Yusri Mohd

AU - Anouar, El Hassane

AU - Awang, Khalijah

AU - Langat, Moses

AU - Cordell, Geoffrey A.

AU - Ahmad, Rohaya

PY - 2019/11/22

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AB - The structure elucidation of three new alkaloids named isoformosaninol (1), formosaninol (2), and longiflorine (3), isolated from the leaves of Uncaria longiflora var. pteropoda (Miq.) Ridsdale, along with their biosynthetic pathways are discussed. Their absolute structures were determined through a combination of physical data interpretation and quantum chemical calculations using the time-dependent density functional theory (TDDFT) method.

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DO - 10.1021/acs.jnatprod.8b00380

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JF - Journal of Natural Products

IS - 11

ER -

Absolute Configuration of Alkaloids from Uncaria longiflora through Experimental and Computational Approaches

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