Abstract
Uncatalyzed Knoevenagel condensation reaction between active methylene compound dimedone (1) and various aromatic/heteroaromatic aldehydes such as 3-pyridinylcarboxaldehyde (2d) in an absolute aqueous condition has been investigated. The reaction performed in a minimum amount of distilled water at boiling temperature provided corresponding arylidene/heteroaromatic derivatives with good purity in high yield. The method is operationally simple, less time consuming and involves eco-friendly conditions. In addition, a model compound was synthesized using various known catalysts under the optimized condition and solvents to compare the results of catalyzed and uncatalyzed reactions.
| Original language | English |
|---|---|
| Pages (from-to) | 165-170 |
| Number of pages | 6 |
| Journal | Indian Journal of Heterocyclic Chemistry |
| Volume | 30 |
| Issue number | 2 |
| State | Published - 2020 |
Keywords
- Aqueous
- Dimedone
- Knoevenagel condensation
- Uncatalyzed