4-nitroso-1-phenyl-3-methyl-2-pyrazolin-5-one in the synthesis of: Some new 4-substituted heterocycles of pharmaceutical interest

M. A. Metwally; M. Hammouda; S. S. El-Morsy; M. M. El-Hussini

4-nitroso-1-phenyl-3-methyl-2-pyrazolin-5-one in the synthesis of: Some new 4-substituted heterocycles of pharmaceutical interest

M. A. Metwally
, M. Hammouda
, S. S. El-Morsy
, M. M. El-Hussini

Mansoura University

Research output: Contribution to journal › Article › peer-review

Abstract

Condensation of 4-nitrosopyrazolone 1 with active methylene components namely, malononitrile, acetophenone, ω-cyano-acetophenone and i or 1,3-diphenylacetone gave compounds 2a-c and 4. Treatment of 2a, b with hydrazine hydrate gave the aminopyrazoles 3a,b. Reaction of 1 with some hydrazines afforded derivatives 5,6,7a, b. While the condensation of 1 with hydrazine hydrate gave the bispyrazolone 8. The structures of the ring systems have been confirmed by their I R, ¹H-NMR and mass spectral data.

Original language	English
Pages (from-to)	511-515
Number of pages	5
Journal	Bollettino Chimico Farmaceutico
Volume	136
Issue number	6
State	Published - Jun 1997
Externally published	Yes

Keywords

nitroso
pyrazolone
reactions

Cite this

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title = "4-nitroso-1-phenyl-3-methyl-2-pyrazolin-5-one in the synthesis of: Some new 4-substituted heterocycles of pharmaceutical interest",

abstract = "Condensation of 4-nitrosopyrazolone 1 with active methylene components namely, malononitrile, acetophenone, ω-cyano-acetophenone and i or 1,3-diphenylacetone gave compounds 2a-c and 4. Treatment of 2a, b with hydrazine hydrate gave the aminopyrazoles 3a,b. Reaction of 1 with some hydrazines afforded derivatives 5,6,7a, b. While the condensation of 1 with hydrazine hydrate gave the bispyrazolone 8. The structures of the ring systems have been confirmed by their I R, 1H-NMR and mass spectral data.",

keywords = "nitroso, pyrazolone, reactions",

author = "Metwally, \{M. A.\} and M. Hammouda and El-Morsy, \{S. S.\} and El-Hussini, \{M. M.\}",

year = "1997",

month = jun,

language = "English",

volume = "136",

pages = "511--515",

journal = "Bollettino Chimico Farmaceutico",

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T1 - 4-nitroso-1-phenyl-3-methyl-2-pyrazolin-5-one in the synthesis of

T2 - Some new 4-substituted heterocycles of pharmaceutical interest

AU - Metwally, M. A.

AU - Hammouda, M.

AU - El-Morsy, S. S.

AU - El-Hussini, M. M.

PY - 1997/6

Y1 - 1997/6

N2 - Condensation of 4-nitrosopyrazolone 1 with active methylene components namely, malononitrile, acetophenone, ω-cyano-acetophenone and i or 1,3-diphenylacetone gave compounds 2a-c and 4. Treatment of 2a, b with hydrazine hydrate gave the aminopyrazoles 3a,b. Reaction of 1 with some hydrazines afforded derivatives 5,6,7a, b. While the condensation of 1 with hydrazine hydrate gave the bispyrazolone 8. The structures of the ring systems have been confirmed by their I R, 1H-NMR and mass spectral data.

AB - Condensation of 4-nitrosopyrazolone 1 with active methylene components namely, malononitrile, acetophenone, ω-cyano-acetophenone and i or 1,3-diphenylacetone gave compounds 2a-c and 4. Treatment of 2a, b with hydrazine hydrate gave the aminopyrazoles 3a,b. Reaction of 1 with some hydrazines afforded derivatives 5,6,7a, b. While the condensation of 1 with hydrazine hydrate gave the bispyrazolone 8. The structures of the ring systems have been confirmed by their I R, 1H-NMR and mass spectral data.

KW - nitroso

KW - pyrazolone

KW - reactions

UR - https://www.scopus.com/pages/publications/0030865323

M3 - Article

AN - SCOPUS:0030865323

SN - 0006-6648

VL - 136

SP - 511

EP - 515

JO - Bollettino Chimico Farmaceutico

JF - Bollettino Chimico Farmaceutico

IS - 6

ER -

4-nitroso-1-phenyl-3-methyl-2-pyrazolin-5-one in the synthesis of: Some new 4-substituted heterocycles of pharmaceutical interest

Abstract

Keywords

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